Patients in a University of Minnesota study were asked to take their CBD dose (300mg for all but one patient who took 200mg) either on an empty stomach (after fasting for at least 10 hours) or with a high-fat meal (a breakfast burrito). After ingestion, blood draws were taken to evaluate CBD levels. Cognitive tests were administered and safety data were also recorded.
Analyses revealed that Cmax, or the maximum CBD concentration in the blood, was 14 times higher after a high-fat meal compared to an empty stomach. In addition, the area under the curve (or AUC) was 4 times higher after a high-fat meal; this measure refers to the amount of drug that was exposed to the body over time. There were no differences in safety or cognition.
Cannabidiol Dosing & The Food Effect - Terpenes and Testing Magazine *